Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 1/20 | 0.40 |
| ▸ | PAK4 | O96013 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.32 |
| ▸ | SLC34A1 | Q06495 | 1/20 | 0.31 |
| ▸ | IGF1R | P08069 | 4/20 | 0.31 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.31 |
| ▸ | KDR | P35968 | 1/20 | 0.31 |
| ▸ | JAK2 | O60674 | 2/20 | 0.30 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL219241 | 0.86 | PLK4 (0.43) | PLK4PAK4MEN1HTTKMT2A | |
| SCHEMBL4073779 | 0.82 | IGF1R (0.42) | PLK4PAK4MEN1HTTKMT2A | |
| SCHEMBL4065934 | 0.82 | PLK4 (0.40) | PLK4PAK4MEN1HTTKMT2A | |
| SCHEMBL4076654 | 0.80 | ALDH1A1 (0.43) | PLK4PAK4MEN1HTTKMT2A | |
| SCHEMBL588674 | 0.77 | PAK4 (0.62) | PLK4PAK4MEN1HTTKMT2A | |
| SCHEMBL3336245 | 0.77 | KCNH2 (0.39) | PLK4PAK4KDM4ENFKB1IGF1R | |
| SCHEMBL3338554 | 0.76 | NTRK1 (0.55) | — | |
| SCHEMBL218646 | 0.75 | PLK4 (0.40) | PLK4PAK4MEN1HTTKMT2A | |
| SCHEMBL4076750 | 0.72 | IGF1R (0.40) | PLK4PAK4MEN1HTTKMT2A | |
| SCHEMBL3663952 | 0.71 | FGFR4 (0.46) | HTTFGFR2IGF1RFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |