Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 8/20 | 0.57 |
| ▸ | TACR2 | P21452 | 1/20 | 0.41 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.38 |
| ▸ | ALPI | P09923 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | XIAP | P98170 | 1/20 | 0.37 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.36 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.36 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 2/20 | 0.35 |
| ▸ | LAP3 | P28838 | 2/20 | 0.35 |
| ▸ | ANPEP | P15144 | 1/20 | 0.35 |
| ▸ | RNPEP | Q9H4A4 | 1/20 | 0.35 |
| ▸ | DNPEP | Q9ULA0 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068618 | 0.89 | CCR1 (0.55) | CCR1SLC15A1CSNK1EEPHX1ALPI | |
| SCHEMBL6687785 | 0.88 | CCR1 (0.56) | CCR1SLC15A1CSNK1EEPHX1ANPEP | |
| SCHEMBL7586283 | 0.88 | CCR1 (0.56) | CCR1SLC15A1CSNK1EEPHX1ANPEP | |
| SCHEMBL4067461 | 0.88 | CCR1 (0.56) | CCR1SLC15A1CSNK1EEPHX1ANPEP | |
| SCHEMBL27586171 | 0.88 | CCR1 (0.56) | CCR1SLC15A1CSNK1EEPHX1ANPEP | |
| SCHEMBL2675154 | 0.88 | CCR1 (0.56) | CCR1SLC15A1CSNK1EEPHX1ANPEP | |
| SCHEMBL4061506 | 0.85 | LMNA (0.46) | CCR1SLC15A1CSNK1EEPHX1REN | |
| SCHEMBL4065521 | 0.83 | CCR1 (0.58) | CCR1SLC15A1CSNK1EEPHX1ALPI | |
| SCHEMBL4066052 | 0.82 | CCR1 (0.42) | CCR1SLC15A1CSNK1EEPHX1ALPI | |
| SCHEMBL4068034 | 0.81 | CCR1 (0.58) | CCR1SLC15A1CSNK1EEPHX1ALPI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0966443-B1 | HETEROARYL-HEXANOIC ACID AMIDE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS SELECTIVE INHIBITORS OF MIP-1-ALPHA BINDING TO ITS CCR1 RECEPTOR | PFIZER (US) | 2009-01-28 | — | — | EP | disclosed |