Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 1/20 | 0.45 |
| ▸ | PARG | Q86W56 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 8/20 | 0.41 |
| ▸ | FEN1 | P39748 | 8/20 | 0.41 |
| ▸ | EDNRB | P24530 | 1/20 | 0.39 |
| ▸ | EDNRA | P25101 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | PRF1 | P14222 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072859 | 0.78 | MAPK10 (0.40) | PARGMAPK10ALOX5APFEN1POLB | |
| SCHEMBL16455996 | 0.76 | TNKS (0.53) | TNKSPOLB | |
| SCHEMBL1884121 | 0.75 | GRIA1 (0.53) | PARGMAPK10ALOX5APFEN1EDNRB | |
| SCHEMBL16456296 | 0.74 | TNKS (0.55) | TNKS | |
| SCHEMBL6677948 | 0.71 | TNKS (0.45) | TNKS | |
| SCHEMBL15758398 | 0.70 | GRIA1 (0.57) | TNKS | |
| SCHEMBL6675172 | 0.70 | TNKS (0.47) | TNKS | |
| SCHEMBL687843 | 0.69 | GRIA1 (0.58) | TNKS | |
| SCHEMBL10628928 | 0.68 | EDNRA (0.56) | ALOX5APFEN1EDNRBEDNRA | |
| SCHEMBL4072861 | 0.68 | MAPK10 (0.44) | PARGMAPK10POLBKAT6AJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300396-B1 | 1,2-DIHYDROPYRIDINE COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF | EISAI R&D MAN CO LTD (JP) | 2009-01-14 | — | — | EP | disclosed |