Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | PARG | Q86W56 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | KAT6A | Q92794 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.35 |
| ▸ | FEN1 | P39748 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | PRF1 | P14222 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6678664 | 0.82 | CA2 (0.46) | LMNA | |
| SCHEMBL3667468 | 0.82 | PARP1 (0.45) | POLBALDH1A1CYP1A2MAPTSMN1; SMN2 | |
| SCHEMBL4072856 | 0.78 | TNKS (0.45) | MAPK10PARGPOLBKAT6AJAK2 | |
| SCHEMBL6680179 | 0.76 | CHEK1 (0.39) | ALDH1A1MAPTSMN1; SMN2L3MBTL1LMNA | |
| SCHEMBL6674838 | 0.74 | CYP2A6 (0.55) | SMN1; SMN2 | |
| SCHEMBL2921725 | 0.72 | CDK2 (0.45) | ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL3667347 | 0.72 | MAPK14 (0.42) | ALDH1A1MAPTSMN1; SMN2JAK2JAK3 | |
| SCHEMBL3665777 | 0.72 | CCNE1 (0.40) | KAT6AALDH1A1SMN1; SMN2JAK3L3MBTL1 | |
| SCHEMBL6691807 | 0.71 | PTGS2 (0.43) | — | |
| SCHEMBL6679862 | 0.71 | SMN1; SMN2 (0.44) | POLBALDH1A1CYP2D6CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1300396-B1 | 1,2-DIHYDROPYRIDINE COMPOUNDS, PROCESS FOR PREPARATION OF THE SAME AND USE THEREOF | EISAI R&D MAN CO LTD (JP) | 2009-01-14 | — | — | EP | disclosed |