Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | CASR | P41180 | 4/20 | 0.49 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | ADRB2 | P07550 | 3/20 | 0.45 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.45 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.43 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL768214 | 0.82 | KMT2A (0.57) | CASRSLC2A1KMT2AMEN1CYP2D6 | |
| SCHEMBL768215 | 0.82 | KMT2A (0.57) | CASRSLC2A1KMT2AMEN1CYP2D6 | |
| SCHEMBL27931862 | 0.75 | MRGPRX4 (0.46) | KMT2AMEN1SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL10890358 | 0.73 | CASR (0.52) | CASRSLC2A1KMT2AMEN1CYP2D6 | |
| SCHEMBL4073362 | 0.72 | ADRB1 (0.45) | KDM4ESLC2A1KMT2AMEN1ADRB2 | |
| SCHEMBL4075604 | 0.72 | MEN1 (0.48) | CASRSLC2A1KMT2AMEN1NPSR1 | |
| SCHEMBL19783047 | 0.71 | MRGPRX4 (0.43) | SLC6A2SLC6A4SLC6A3NPSR1MRGPRX4 | |
| SCHEMBL11159125 | 0.71 | MRGPRX4 (0.50) | KDM4EKMT2ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL11594729 | 0.70 | KMT2A (0.65) | KDM4EKMT2AMEN1ADRB2NPSR1 | |
| SCHEMBL772493 | 0.70 | KMT2A (0.61) | KDM4ECASRKMT2AMEN1CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066673-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | ChemBridge Research Laboratories, Inc. (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008021369-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2008-02-21 | — | — | WO | disclosed |