Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CASR | P41180 | 2/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4080566 | 0.83 | ALOX15 (0.41) | MEN1KMT2AALDH1A1ALOX15PKM | |
| SCHEMBL768596 | 0.81 | KMT2A (0.52) | MEN1KMT2AALDH1A1ALOX15NPSR1 | |
| SCHEMBL768595 | 0.81 | KMT2A (0.52) | MEN1KMT2AALDH1A1ALOX15NPSR1 | |
| SCHEMBL4072956 | 0.72 | KDM4E (0.50) | MEN1KMT2AALDH1A1NPSR1PKM | |
| SCHEMBL4076693 | 0.72 | ALOX15 (0.43) | MEN1KMT2AALDH1A1ALOX15CASR | |
| SCHEMBL4078537 | 0.71 | KDM4E (0.39) | KMT2AALDH1A1ALOX15HTTCASR | |
| SCHEMBL4082452 | 0.71 | MAPT (0.41) | KMT2AALDH1A1ALOX15CYP1A2 | |
| SCHEMBL19607313 | 0.71 | ADRB3 (0.38) | KMT2AALDH1A1ALOX15 | |
| SCHEMBL4078535 | 0.70 | ADRB1 (0.46) | MEN1KMT2AALOX15 | |
| SCHEMBL23363940 | 0.69 | ADRA1D (0.39) | ALDH1A1NPSR1PKMADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066673-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | ChemBridge Research Laboratories, Inc. (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008021369-A2 | TRICYCLIC COMPOUNDS AND ITS USE AS TYROSINE KINASE MODULATORS | CHEMBRIDGE RESEARCH LABORATORIES, INC. (US) | 2008-02-21 | — | — | WO | disclosed |