SCHEMBL4073260

SCHEMBL4073260

O=CC(c1ccc(Br)cc1)N1CCOCC1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 1/20 0.41
NPC1 O15118 1/20 0.41
RAB9A P51151 1/20 0.41
MAPT P10636 2/20 0.40
POLB P06746 1/20 0.40
AKR1C3 P42330 1/20 0.40
CYP1A1 P04798 1/20 0.39
CYP1B1 Q16678 1/20 0.39
PHGDH O43175 1/20 0.39
HSP90AA1 P07900 1/20 0.37
NTSR1 P30989 1/20 0.37
ALDH1A1 P00352 3/20 0.37
LMNA P02545 2/20 0.37
KMT2A Q03164 2/20 0.37
TP53 P04637 1/20 0.37
MPI P34949 1/20 0.37
MEN1 O00255 1/20 0.37
TSHR P16473 1/20 0.37
HTT P42858 1/20 0.37
AAK1 Q2M2I8 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2646794 0.84 SLC6A2 (0.39) NPC1RAB9AMAPTALDH1A1LMNA
SCHEMBL6631373 0.83 NPC1 (0.37) NPC1RAB9AMAPTALDH1A1TSHR
SCHEMBL12068487 0.83 ALDH1A1 (0.50) ALDH1A1LMNATSHRGRM5
SCHEMBL1516145 0.83 ALDH1A1 (0.50) ALDH1A1LMNATSHRGRM5
SCHEMBL16969029 0.82 ALDH1A1 (0.36) NPC1RAB9AALDH1A1TSHRHTT
SCHEMBL4066868 0.81 ALDH1A1 (0.39) ALDH1A1LMNAKMT2AMEN1TSHR
Hydrochloric Acid SCHEMBL68317 0.81 ALDH1A1 (0.53) HSP90AA1ALDH1A1LMNATSHRHTT
SCHEMBL4062782 0.81 KMT2A (0.45) MGLLNPC1RAB9AMAPTPOLB
SCHEMBL15286386 0.80 ALDH1A1 (0.41) NPC1RAB9AMAPTPOLBHSP90AA1
SCHEMBL17338815 0.80 MIF (0.46) AKR1C3ALDH1A1LMNAHTTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3154941-A1 SMALL MOLECULE LFA-1 INHIBITORS AlloCyte Pharmaceuticals AG (CH) 2017-04-19 EP disclosed
EP-3016946-A1 SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF Karyopharm Therapeutics, Inc. (US) 2016-05-11 EP disclosed
WO-2015189265-A1 SMALL MOLECULE LFA-1 INHIBITORS ALLOCYTE PHARMACEUTICALS AG (CH) 2015-12-17 WO disclosed
WO-2015003166-A1 SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF Karyopharm Therapeutics Inc. (US) 2015-01-08 WO disclosed
EP-2049118-A1 MORPHOLINYL AND PYRROLIDINYL ANALOGS SmithKline Beecham Corporation (US) 2009-04-22 EP disclosed
WO-2008011551-A1 MORPHOLINYL AND PYRROLIDINYL ANALOGS SMITHKLINE BEECHAM CORPORATION (US) 2008-01-24 WO disclosed
EP-1421074-A1 NOVEL COMPOUNDS AstraZeneca AB (SE) 2004-05-26 EP disclosed
WO-2003010158-A1 NOVEL COMPOUNDS ASTRAZENECA AB (SE) 2003-02-06 WO disclosed