SCHEMBL4066868

SCHEMBL4066868

O=CC(c1cccc(Br)c1)N1CCOCC1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.39
HTT P42858 2/20 0.39
PRKDC P78527 1/20 0.38
MBTD1 Q05BQ5 1/20 0.37
L3MBTL3 Q96JM7 1/20 0.37
LMNA P02545 1/20 0.36
HPGD P15428 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
MTOR P42345 1/20 0.36
AAK1 Q2M2I8 1/20 0.36
KCNA5 P22460 1/20 0.36
KMT2A Q03164 2/20 0.36
MEN1 O00255 1/20 0.36
DUSP3 P51452 1/20 0.36
PTPN5 P54829 1/20 0.36
PTPN11 Q06124 1/20 0.36
CYP3A4 P08684 1/20 0.35
TSHR P16473 1/20 0.35
CYP2C19 P33261 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4068782 0.86 MBTD1 (0.46) ALDH1A1MBTD1L3MBTL3LMNAHPGD
SCHEMBL3580010 0.82 SLC6A3 (0.42) ALDH1A1HTTMBTD1L3MBTL3SMN1; SMN2
SCHEMBL4073260 0.81 MGLL (0.41) ALDH1A1HTTLMNASMN1; SMN2AAK1
SCHEMBL1516145 0.81 ALDH1A1 (0.50) ALDH1A1LMNAL3MBTL1KCNA5CYP3A4
SCHEMBL12068487 0.81 ALDH1A1 (0.50) ALDH1A1LMNAL3MBTL1KCNA5CYP3A4
Hydrochloric Acid SCHEMBL68317 0.80 ALDH1A1 (0.53) ALDH1A1HTTLMNAL3MBTL1KCNA5
SCHEMBL5239630 0.78 KDM4E (0.49) ALDH1A1LMNASMN1; SMN2L3MBTL1KMT2A
SCHEMBL27754552 0.77 HSP90AA1 (0.46) ALDH1A1HTTHPGDSMN1; SMN2L3MBTL1
SCHEMBL4065914 0.77 MEN1 (0.37) ALDH1A1LMNASMN1; SMN2AAK1KMT2A
SCHEMBL8251020 0.77 MBTD1 (0.59) ALDH1A1HTTMBTD1L3MBTL3MTOR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2049118-A1 MORPHOLINYL AND PYRROLIDINYL ANALOGS SmithKline Beecham Corporation (US) 2009-04-22 EP disclosed
WO-2008011551-A1 MORPHOLINYL AND PYRROLIDINYL ANALOGS SMITHKLINE BEECHAM CORPORATION (US) 2008-01-24 WO disclosed
EP-0971892-A1 NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM Astra Pharmaceuticals Limited (GB) 2000-01-19 EP disclosed
WO-1998042670-A1 NOVEL PYRIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM ASTRA PHARMACEUTICALS LTD. (GB) 1998-10-01 WO disclosed