Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | PGR | P06401 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
| ▸ | FPR1 | P21462 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | TNF | P01375 | 2/20 | 0.34 |
| ▸ | LITAF | Q99732 | 2/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | RORA | P35398 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | RORB | Q92753 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | CNR2 | P34972 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1817311 | 0.86 | HSD11B1 (0.52) | HSD11B1MEN1KMT2APGRLMNA | |
| SCHEMBL3990138 | 0.85 | HSD11B1 (0.55) | HSD11B1MEN1KMT2APGRSMN1; SMN2 | |
| SCHEMBL1819589 | 0.81 | HSD11B1 (0.58) | HSD11B1MEN1KMT2APGRLMNA | |
| SCHEMBL1820439 | 0.80 | HSD11B1 (0.62) | HSD11B1MEN1KMT2APGRLMNA | |
| SCHEMBL1819650 | 0.79 | HSD11B1 (0.51) | HSD11B1MEN1KMT2APGRLMNA | |
| SCHEMBL2922023 | 0.78 | HSD11B1 (0.57) | HSD11B1MEN1KMT2APGRLMNA | |
| SCHEMBL2918183 | 0.77 | HSD11B1 (0.78) | HSD11B1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL2922619 | 0.77 | HSD11B1 (0.46) | HSD11B1MEN1KMT2ALMNASMN1; SMN2 | |
| SCHEMBL2924132 | 0.76 | HSD11B1 (0.57) | HSD11B1MEN1KMT2APGRLMNA | |
| SCHEMBL2915813 | 0.76 | HSD11B1 (0.79) | HSD11B1MEN1KMT2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1828197-B1 | NOVEL SUBSTITUTED THIOPHENEPYRIMIDINONE DERIVATIVES AS INHIBITORS OF 17ß-HYDROXYSTEROID DEHYDROGENASE | SOLVAY PHARM GMBH (DE) | 2009-05-13 | — | — | EP | disclosed |