Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 13/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.40 |
| ▸ | ESR1 | P03372 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1009044 | 0.87 | GRM5 (0.51) | GRM5ALDH1A1ESR2ESR1POLB | |
| SCHEMBL1010219 | 0.87 | GRM5 (0.57) | GRM5ALDH1A1ESR2ESR1POLB | |
| SCHEMBL1010423 | 0.87 | GRM5 (0.48) | GRM5ALDH1A1ESR2ESR1POLB | |
| SCHEMBL1010349 | 0.86 | GRM5 (0.53) | GRM5ALDH1A1ESR2ESR1POLB | |
| SCHEMBL4464614 | 0.86 | ALDH1A1 (0.34) | GRM5ALDH1A1MAPTTSHRKMT2A | |
| SCHEMBL1010001 | 0.85 | GRM5 (0.49) | GRM5ALDH1A1ESR2TDP1GAA | |
| SCHEMBL1010133 | 0.83 | GRM5 (0.48) | GRM5ALDH1A1ESR2TDP1GAA | |
| SCHEMBL1010766 | 0.82 | GRM5 (0.46) | GRM5ALDH1A1ESR2ESR1POLB | |
| SCHEMBL1009049 | 0.81 | GRM5 (0.51) | GRM5ALDH1A1ESR2ESR1POLB | |
| SCHEMBL1009983 | 0.80 | GRM5 (0.53) | GRM5ALDH1A1ESR2ESR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054416-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | Merz Pharma GmbH & Co. KGaA (DE) | 2009-05-06 | — | — | EP | claimed |
| WO-2008015269-A1 | SUBSTITUTED PYRAZOLOPYRIMIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINE | MERZ PHARMA GMBH & CO. KGAA (DE) | 2008-02-07 | — | — | WO | claimed |