Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | DRD1 | P21728 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 3/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | GRM5 | P41594 | 4/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.30 |
| ▸ | TRPC6 | Q9Y210 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3817104 | 0.87 | ALDH1A1 (0.36) | ALDH1A1LMNATSHRMAPK1NPSR1 | |
| SCHEMBL3815643 | 0.87 | MAPT (0.38) | ALDH1A1LMNATSHRMAPK1NPSR1 | |
| SCHEMBL3814000 | 0.87 | GRM5 (0.39) | LMNAMAPK1DRD1KMT2AMEN1 | |
| SCHEMBL3810902 | 0.86 | KMT2A (0.41) | ALDH1A1LMNATSHRMAPK1KMT2A | |
| SCHEMBL4073986 | 0.86 | GRM5 (0.45) | ALDH1A1TSHRKMT2AMAPTGRM5 | |
| SCHEMBL3810668 | 0.85 | KMT2A (0.41) | ALDH1A1LMNATSHRMAPK1DRD1 | |
| SCHEMBL3818792 | 0.83 | KMT2A (0.39) | LMNAMAPK1DRD1KMT2AMEN1 | |
| SCHEMBL3816607 | 0.83 | KMT2A (0.42) | LMNAMAPK1DRD1KMT2AMEN1 | |
| SCHEMBL3813529 | 0.82 | F11 (0.40) | ALDH1A1TSHRMAPK1NPSR1DRD1 | |
| SCHEMBL3819045 | 0.80 | GRM5 (0.36) | ALDH1A1LMNATSHRMAPK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009095253-A1 | 6-HALO-PYRAZOLO[1, 5-A]PYRIDINES, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS METABOTROPIC GLUTAMATE RECEPTOR (MGLUR) MODULATORS | MERZ PHARMA GMBH & CO. KGAA (DE) | 2009-08-06 | — | — | WO | disclosed |