Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 6/20 | 0.37 |
| ▸ | CTSC | P53634 | 6/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 2/20 | 0.35 |
| ▸ | NTRK2 | Q16620 | 2/20 | 0.35 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 1/20 | 0.35 |
| ▸ | FYN | P06241 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | FLT1 | P17948 | 1/20 | 0.35 |
| ▸ | LTK | P29376 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 1/20 | 0.35 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.35 |
| ▸ | CLK2 | P49760 | 1/20 | 0.35 |
| ▸ | CDK7 | P50613 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4076754 | 0.86 | STK17B (0.38) | JAK2NTRK1AURKANTRK3NTRK2 | |
| SCHEMBL2062060 | 0.78 | JAK2 (0.40) | JAK2NTRK1AURKANTRK3NTRK2 | |
| SCHEMBL1771025 | 0.76 | NTRK1 (0.47) | JAK2NTRK1CTSCAURKAIGF1R | |
| SCHEMBL3339774 | 0.74 | JAK2 (0.42) | JAK2NTRK1AURKANTRK3NTRK2 | |
| SCHEMBL27674619 | 0.74 | GABRA1 (0.38) | AURKAIGF1RROCK1 | |
| SCHEMBL3852710 | 0.73 | IGF1R (0.41) | JAK2NTRK1AURKANTRK3NTRK2 | |
| SCHEMBL217976 | 0.71 | JAK2 (0.39) | JAK2NTRK1CTSCAURKAIGF1R | |
| SCHEMBL5778429 | 0.70 | IGF1R (0.37) | JAK2NTRK1IGF1RALK | |
| SCHEMBL3337893 | 0.69 | BCL6 (0.38) | JAK2NTRK1CTSCAURKANTRK3 | |
| SCHEMBL29019907 | 0.69 | CTSC (0.53) | CTSCAURKAATF1NFKB1BCL6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |