Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 13/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | JAK3 | P52333 | 1/20 | 0.41 |
| ▸ | GRK6 | P43250 | 5/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.38 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4071743 | 0.86 | NTRK1 (0.47) | NTRK1JAK2JAK3GRK6ADRA1D | |
| SCHEMBL4072134 | 0.85 | NTRK1 (0.48) | NTRK1JAK2JAK3GRK6ADRA1D | |
| SCHEMBL4159909 | 0.85 | NTRK1 (0.57) | NTRK1JAK2JAK3 | |
| SCHEMBL23217059 | 0.82 | NTRK1 (0.52) | NTRK1JAK2JAK3 | |
| SCHEMBL30010123 | 0.82 | NTRK1 (0.52) | NTRK1JAK2JAK3 | |
| SCHEMBL4491060 | 0.78 | NTRK1 (0.41) | NTRK1JAK2JAK3GRK6ADRA1D | |
| SCHEMBL2511149 | 0.78 | NTRK1 (0.41) | NTRK1JAK2JAK3GRK6ADRA1D | |
| SCHEMBL1792113 | 0.78 | IGF1R (0.57) | NTRK1 | |
| SCHEMBL4151807 | 0.77 | NTRK1 (0.54) | NTRK1JAK2JAK3 | |
| SCHEMBL3338317 | 0.76 | NTRK1 (0.45) | NTRK1JAK2JAK3GRK6ADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |