Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 16/20 | 0.62 |
| ▸ | CTSS | P25774 | 8/20 | 0.51 |
| ▸ | CTSK | P43235 | 8/20 | 0.51 |
| ▸ | CTSB | P07858 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL346810 | 0.81 | CTSS (0.62) | CTSLCTSSCTSKCTSB | |
| SCHEMBL6182672 | 0.77 | CTSL (0.91) | CTSLCTSSCTSKCTSB | |
| SCHEMBL4243053 | 0.77 | CTSL (1.00) | CTSLCTSSCTSKCTSB | |
| SCHEMBL8218549 | 0.77 | CTSL (1.00) | CTSLCTSSCTSKCTSB | |
| SCHEMBL346969 | 0.76 | CTSL (0.69) | CTSLCTSSCTSKCTSB | |
| SCHEMBL17060574 | 0.76 | CTSS (0.73) | CTSLCTSSCTSKCTSB | |
| SCHEMBL23694015 | 0.73 | CTSL (0.64) | CTSLCTSSCTSKCTSB | |
| SCHEMBL6183597 | 0.72 | CTSL (0.67) | CTSLCTSSCTSKCTSB | |
| SCHEMBL10187872 | 0.70 | CTSS (0.72) | CTSLCTSSCTSKCTSB | |
| SCHEMBL8224461 | 0.68 | CTSS (0.72) | CTSLCTSSCTSKCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2520568-B1 | Spirocyclic nitriles as inhibitors of protease | SANOFI SA (FR) | 2015-09-09 | — | — | EP | claimed |
| EP-2520568-A1 | Spirocyclic nitriles as inhibitors of protease | SANOFI (FR) | 2012-11-07 | — | — | EP | claimed |
| EP-2032535-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | Sanofi-Aventis (FR) | 2009-03-11 | — | — | EP | claimed |
| WO-2007137738-A1 | SPIROCYCLIC NITRILES AS PROTEASE INHIBITORS | SANOFI-AVENTIS (DE) | 2007-12-06 | — | — | WO | claimed |
| EP-2520568-B1 | Spirocyclic nitriles as inhibitors of protease | SANOFI SA (FR) | 2015-09-09 | — | — | EP | disclosed |