Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.43 |
| ▸ | HTR2B | P41595 | 4/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.40 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.37 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6374267 | 0.84 | HTR2C (0.42) | HTR2CHTR2BHTR2AHRH3HPGD | |
| SCHEMBL28643716 | 0.80 | HRH3 (0.39) | HTR2CHTR2BHTR2AHRH3CYP2D6 | |
| SCHEMBL2657988 | 0.78 | SLC18A3 (0.53) | HTR2CHTR2BHTR2ATAAR1HRH3 | |
| SCHEMBL29501341 | 0.78 | SLC18A3 (0.53) | HTR2CHTR2BHTR2ATAAR1HRH3 | |
| SCHEMBL2491465 | 0.77 | HRH3 (0.47) | HTR2CHTR2BHRH3CYP2D6 | |
| Bromide SCHEMBL6423364 | 0.76 | SLC18A3 (0.51) | HTR2CHTR2BHTR2ATAAR1HRH3 | |
| Hydrochloric Acid SCHEMBL5271851 | 0.76 | SLC18A3 (0.51) | HTR2CHTR2BHTR2ATAAR1HRH3 | |
| Hydrochloric Acid SCHEMBL29877056 | 0.76 | SLC18A3 (0.51) | HTR2CHTR2BHTR2ATAAR1HRH3 | |
| Hydrochloric Acid SCHEMBL16835555 | 0.76 | SLC18A3 (0.51) | HTR2CHTR2BHTR2ATAAR1HRH3 | |
| SCHEMBL28186450 | 0.75 | HRH3 (0.36) | HTR2CHTR2BHRH3CYP2D6L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009020470-A2 | CGRP RECEPTOR ANTAGONISTS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2009-02-12 | — | — | WO | disclosed |