Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRK2 | P25098 | 5/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | ATM | Q13315 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13569028 | 1.00 | GRK2 (0.62) | GRK2SMN1; SMN2MAPTKMT2APOLB | |
| SCHEMBL13569037 | 0.88 | RAB9A (0.66) | GRK2SMN1; SMN2MAPTKMT2APOLB | |
| SCHEMBL13568880 | 0.88 | RAB9A (0.60) | SMN1; SMN2MAPTKMT2APOLBMEN1 | |
| SCHEMBL4082049 | 0.88 | RAB9A (0.66) | GRK2SMN1; SMN2MAPTKMT2APOLB | |
| SCHEMBL4074184 | 0.88 | RAB9A (0.60) | SMN1; SMN2MAPTKMT2APOLBMEN1 | |
| SCHEMBL13568977 | 0.83 | MEN1 (0.48) | SMN1; SMN2MAPTKMT2APOLBALDH1A1 | |
| SCHEMBL4073741 | 0.83 | MEN1 (0.48) | SMN1; SMN2MAPTKMT2APOLBALDH1A1 | |
| SCHEMBL13568966 | 0.81 | POLB (0.50) | SMN1; SMN2MAPTKMT2APOLBMEN1 | |
| SCHEMBL13568915 | 0.81 | MAPT (0.58) | SMN1; SMN2MAPTKMT2APOLBALDH1A1 | |
| SCHEMBL4074120 | 0.81 | MAPT (0.58) | SMN1; SMN2MAPTKMT2APOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009155362-A1 | SMALL MOLECULE HEMATOPOIETIC GROWTH FACTOR MIMETIC COMPOUNDS AND THEIR USES | LIGAND PHARMACEUTICALS INC. (US) | 2009-12-23 | — | — | WO | disclosed |