Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 5/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | TNIK | Q9UKE5 | 3/20 | 0.34 |
| ▸ | ADH5 | P11766 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.33 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.33 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.33 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.33 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.33 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883565 | 0.89 | TNIK (0.35) | TTKJAK1PDE3BPDE3AIGF1R | |
| SCHEMBL3973909 | 0.82 | TTK (0.58) | TTKJAK1JAK2JAK3 | |
| SCHEMBL4073923 | 0.81 | TTK (0.40) | TTKJAK1PDE3BPDE3AIGF1R | |
| SCHEMBL13883496 | 0.80 | JAK2 (0.38) | TTKJAK1JAK2JAK3TNIK | |
| SCHEMBL13883701 | 0.79 | TTK (0.39) | TTKJAK1JAK2JAK3TNIK | |
| SCHEMBL13883515 | 0.77 | TTK (0.45) | TTKJAK2JAK3 | |
| SCHEMBL4085413 | 0.76 | TTK (0.38) | TTKJAK1JAK2HDAC1HDAC6 | |
| SCHEMBL13883716 | 0.76 | AXL (0.45) | JAK1JAK2JAK3HDAC1HDAC6 | |
| SCHEMBL3973968 | 0.72 | KDR (0.43) | TTKJAK1JAK2JAK3ACVR1 | |
| SCHEMBL13883586 | 0.68 | CYP11B1 (0.42) | TTKJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |