Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTK | P33981 | 8/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.35 |
| ▸ | JAK2 | O60674 | 4/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.34 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | CD38 | P28907 | 1/20 | 0.33 |
| ▸ | IKBKB | O14920 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883701 | 0.85 | TTK (0.39) | TTKJAK2JAK1CYP1A1CYP1A2 | |
| SCHEMBL3971407 | 0.80 | TTK (0.61) | TTKJAK2JAK1FLT3 | |
| SCHEMBL4073923 | 0.80 | TTK (0.40) | TTKJAK2JAK1CYP1A1CYP1A2 | |
| SCHEMBL4075295 | 0.76 | TTK (0.38) | TTKJAK2JAK1HDAC1HDAC6 | |
| SCHEMBL4410518 | 0.76 | L3MBTL1 (0.34) | JAK2FLT3CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL13883565 | 0.72 | TNIK (0.35) | TTKJAK2JAK1HDAC1HDAC6 | |
| SCHEMBL3970311 | 0.67 | TTK (0.66) | TTKJAK2JAK1 | |
| SCHEMBL3975589 | 0.66 | TTK (0.58) | TTKJAK2JAK1FLT3 | |
| SCHEMBL13883586 | 0.65 | CYP11B1 (0.42) | TTKJAK1CYP1A1CYP1A2CYP1B1 | |
| SCHEMBL13883551 | 0.65 | TUBB4A (0.41) | TTKJAK2JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |