SCHEMBL4075315

COCCOc1ccc(-c2nccc3c(-c4ccc(F)cc4F)ccnc23)c(C)c1.COc1ccccc1-c1nccc2c(-c3ccc(F)cc3F)ccnc12.Cc1cc(O)ccc1-c1nccc2c(-c3ccc(F)cc3F)ccnc12.Fc1ccc(-c2ccnc3c(-c4c(F)cccc4F)nccc23)c(F)c1.Fc1ccc(-c2ccnc3c(-c4cccc5c4OCO5)nccc23)c(F)c1

nearest known ligand 0.42

Predicted protein targets (top 9)

	gene	UniProt	supporting neighbours	confidence
▸	MAPK14	Q16539	12/20	0.42

▸	MAPT	P10636	2/20	0.34

▸	MAPK1	P28482	2/20	0.34

▸	NPSR1	Q6W5P4	2/20	0.34

▸	APP	P05067	1/20	0.31

▸	ACHE	P22303	1/20	0.31

▸	KDM4E	B2RXH2	1/20	0.30

▸	POLB	P06746	1/20	0.30

▸	HTR7	P34969	1/20	0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL4395101	0.89	MAPK14 (0.57)	MAPK14
SCHEMBL2080178	0.77	MAPK14 (0.53)	MAPK14
SCHEMBL2080724	0.75	MAPK14 (0.49)	MAPK14
SCHEMBL4068360	0.75	MAPK14 (0.62)	MAPK14
SCHEMBL4067939	0.72	MAPK14 (0.60)	MAPK14
SCHEMBL2079875	0.71	MAPK14 (0.66)	MAPK14
SCHEMBL2080402	0.71	MAPK14 (0.51)	MAPK14KDM4E
SCHEMBL2079342	0.68	MAPK14 (0.66)	MAPK14
SCHEMBL2078751	0.68	MAPK14 (0.65)	MAPK14
SCHEMBL4067333	0.67	MAPK14 (0.59)	MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-2049537-A1	1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS	Laboratorios Almirall, S.A. (ES)	2009-04-22	—	—	EP	claimed
WO-2008017461-A1	1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS	LABORATORIOS ALMIRALL, S.A. (ES)	2008-02-14	—	—	WO	claimed