Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 11/20 | 0.40 |
| ▸ | MERTK | Q12866 | 2/20 | 0.37 |
| ▸ | AXL | P30530 | 1/20 | 0.37 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.36 |
| ▸ | SELP | P16109 | 1/20 | 0.36 |
| ▸ | NR2F2 | P24468 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | ULK1 | O75385 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | XBP1 | P17861 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4068769 | 0.86 | NR2F2 (0.51) | SYKMERTKAXLTYRO3NR2F2 | |
| SCHEMBL4073787 | 0.79 | CDK4 (0.51) | SYKCDK4CDK6CCND1CCND2 | |
| SCHEMBL4069730 | 0.78 | CDK4 (0.57) | SYKJAK3CDK4CDK6FLT3 | |
| SCHEMBL4066946 | 0.77 | IGF1R (0.46) | SYKULK1 | |
| SCHEMBL4068205 | 0.77 | ULK1 (0.43) | SYKMERTKTYRO3ULK1JAK2 | |
| SCHEMBL4071475 | 0.74 | SYK (0.49) | SYKCDK4CDK6CCND1CCND2 | |
| SCHEMBL4075543 | 0.70 | SYK (0.53) | SYKJAK3CDK4CDK6FLT3 | |
| SCHEMBL4066054 | 0.66 | CDK4 (0.67) | SYKNR2F2NPSR1KDM4EMAPT | |
| SCHEMBL4071876 | 0.66 | CDK4 (0.56) | SYKNR2F2NPSR1KDM4EMAPT | |
| Hydrochloric Acid SCHEMBL4066040 | 0.65 | CDK4 (0.67) | SYKNR2F2NPSR1KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1590341-B1 | 2-AMINOPYRIDINE SUBSTITUTED HETEROCYCLES AS INHIBITORS OF CELLULAR PROLIFERATION | WARNER LAMBERT CO (US) | 2009-06-17 | — | — | EP | claimed |