Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 2/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ELANE | P08246 | 1/20 | 0.39 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 2/20 | 0.38 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.37 |
| ▸ | DAO | P14920 | 1/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.36 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3415322 | 0.84 | KDM4E (0.53) | PARP1FGFR1FGFR4KDM4EELANE | |
| SCHEMBL31037735 | 0.84 | KDM4E (0.53) | PARP1FGFR1FGFR4KDM4EELANE | |
| SCHEMBL14262719 | 0.83 | FGFR1 (0.50) | PARP1FGFR1FGFR4KDM4EELANE | |
| SCHEMBL13663047 | 0.77 | PARP1 (0.47) | PARP1FGFR1FGFR4KDM4EKDM4D | |
| SCHEMBL28419879 | 0.76 | PARP1 (0.46) | PARP1FGFR1FGFR4KDM4EKDM4D | |
| SCHEMBL29640851 | 0.75 | FGFR1 (0.44) | PARP1FGFR1FGFR4KDM4EELANE | |
| SCHEMBL8428527 | 0.75 | FGFR1 (0.44) | PARP1FGFR1FGFR4KDM4EELANE | |
| SCHEMBL17981551 | 0.75 | FGFR1 (0.50) | PARP1FGFR1FGFR4KDM4EELANE | |
| Indazole Carboxamide SCHEMBL42505 | 0.73 | SLC22A12 (0.53) | ELANESLC22A12DAOCLK4DYRK1B | |
| SCHEMBL23227964 | 0.72 | KDM4E (0.55) | PARP1FGFR1FGFR4KDM4EKDM4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2009196932-A | PYRAZOLO[3,4-b]PYRIDINE AMIDE COMPOUND WITH HISTAMINE H4 RECEPTOR ANTAGONISTIC ACTION | KOWA CO | 2009-09-03 | — | — | JP | disclosed |
| EP-1056724-B1 | SUBSTITUTED CYCLOALKYL-4-OXONICOTINIC CARBOXAMIDES; GABA BRAIN RECEPTOR LIGANDS | NEUROGEN CORP (US) | 2005-05-25 | — | — | EP | disclosed |
| EP-0180318-B1 | AMIDE DERIVATIVES | ICI AMERICAS INC. (US) | 1991-11-06 | — | — | EP | disclosed |
| US-4745121-A | AMINE OR CARBOXAMIDE SUBSTITUTED | ICI AMERICAS INC. (US) | 1988-05-17 | — | — | US | disclosed |
| US-4745121-A | AMINE OR CARBOXAMIDE SUBSTITUTED | ICI AMERICAS INC. (US) | 1988-05-17 | — | — | US | disclosed |
| EP-0180318-A1 | Amide derivatives | ICI AMERICAS INC. (US) | 1986-05-07 | — | — | EP | disclosed |