Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 2/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.32 |
| ▸ | CKS1B | P61024 | 1/20 | 0.32 |
| ▸ | SKP1 | P63208 | 1/20 | 0.32 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.32 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.31 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6601505 | 0.75 | POLB (0.44) | PAX8BRD4GPR119LMNAPOLB | |
| SCHEMBL29659142 | 0.75 | POLB (0.44) | PAX8BRD4GPR119LMNAPOLB | |
| SCHEMBL852406 | 0.74 | PAX8 (0.42) | PAX8BRD4CREBBPRAB9AMEN1 | |
| SCHEMBL2424189 | 0.74 | PAX8 (0.34) | PAX8BRD4CREBBP | |
| SCHEMBL68085 | 0.74 | PAX8 (0.42) | PAX8BRD4CREBBPCKS1BSKP1 | |
| SCHEMBL21964982 | 0.73 | PAX8 (0.41) | PAX8BRD4CREBBPCKS1BSKP1 | |
| SCHEMBL20477499 | 0.73 | PAX8 (0.36) | PAX8BRD4CKS1BSKP1SKP2 | |
| SCHEMBL4064565 | 0.72 | PAX8 (0.34) | PAX8BRD4GPR119 | |
| SCHEMBL12853542 | 0.72 | KDM4E (0.46) | PAX8BRD4CREBBPCKS1BSKP1 | |
| SCHEMBL4072458 | 0.72 | NR1I2 (0.42) | PAX8BRD4CREBBPLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049490-A1 | N-(BENZOYL)-O- [2- (PYRIDIN- 2 -YLAMINO) ETHYL]-L-TYROSINE DERIVATIVES AND RELATED COMPOUNDS AS A5B1 ANTAGONISTS FOR THE TREATMENT OF SOLID TUMORS | Astra Zeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2007141473-A1 | N-(BENZOYL)-O- [2- (PYRIDIN- 2 -YLAMINO) ETHYL] -L-TYROSINE DERIVATIVES AND RELATED COMPOUNDS AS A5B1 ANTAGONISTS FOR THE TREATMENT OF SOLID TUMORS | ASTRAZENECA AB (SE) | 2007-12-13 | — | — | WO | disclosed |