Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.32 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.32 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | TTK | P33981 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8234275 | 0.79 | PAX8 (0.38) | PAX8ITGA4ITGB7MTNR1AMTNR1B | |
| SCHEMBL17467147 | 0.75 | PAX8 (0.37) | PAX8ITGA4ITGB7MTNR1AMTNR1B | |
| SCHEMBL15587576 | 0.75 | PAX8 (0.37) | PAX8ITGA4ITGB7MTNR1AMTNR1B | |
| SCHEMBL4076647 | 0.72 | PAX8 (0.39) | PAX8GPR119BRD4 | |
| SCHEMBL4070313 | 0.71 | ALDH1A1 (0.40) | PAX8ITGA4ITGB7MTNR1AMTNR1B | |
| SCHEMBL8226698 | 0.71 | MTNR1A (0.35) | PAX8ITGA4ITGB7MTNR1AMTNR1B | |
| SCHEMBL27808345 | 0.69 | LIPE (0.46) | PAX8ITGA4ITGB7BRD4 | |
| SCHEMBL2848178 | 0.69 | KDM4E (0.36) | MTNR1AMTNR1BBRD4KDM4E | |
| SCHEMBL15587736 | 0.69 | AAK1 (0.35) | PAX8MTNR1AMTNR1BBRD4TTK | |
| SCHEMBL8236816 | 0.68 | KMT2A (0.40) | MTNR1AMTNR1BKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049490-A1 | N-(BENZOYL)-O- [2- (PYRIDIN- 2 -YLAMINO) ETHYL]-L-TYROSINE DERIVATIVES AND RELATED COMPOUNDS AS A5B1 ANTAGONISTS FOR THE TREATMENT OF SOLID TUMORS | Astra Zeneca AB (SE) | 2009-04-22 | — | — | EP | disclosed |
| WO-2007141473-A1 | N-(BENZOYL)-O- [2- (PYRIDIN- 2 -YLAMINO) ETHYL] -L-TYROSINE DERIVATIVES AND RELATED COMPOUNDS AS A5B1 ANTAGONISTS FOR THE TREATMENT OF SOLID TUMORS | ASTRAZENECA AB (SE) | 2007-12-13 | — | — | WO | disclosed |