Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD3 | P35462 | 18/20 | 0.59 |
| ▸ | DRD2 | P14416 | 8/20 | 0.59 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.59 |
| ▸ | HTR2A | P28223 | 11/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3079870 | 1.00 | DRD3 (0.59) | DRD3DRD2KCNH2HTR2A | |
| SCHEMBL3964940 | 0.89 | DRD3 (0.66) | DRD3DRD2KCNH2HTR2A | |
| SCHEMBL3080569 | 0.89 | DRD3 (0.66) | DRD3DRD2KCNH2HTR2A | |
| SCHEMBL4076666 | 0.83 | DRD2 (0.56) | DRD3DRD2HTR2A | |
| SCHEMBL228992 | 0.83 | DRD3 (0.64) | DRD3DRD2KCNH2HTR2A | |
| SCHEMBL228993 | 0.83 | DRD3 (0.64) | DRD3DRD2KCNH2HTR2A | |
| SCHEMBL228444 | 0.82 | DRD3 (0.61) | DRD3DRD2KCNH2HTR2A | |
| SCHEMBL228986 | 0.81 | DRD3 (0.63) | DRD3DRD2KCNH2HTR2A | |
| SCHEMBL14715784 | 0.80 | DRD3 (0.60) | DRD3DRD2HTR2A | |
| SCHEMBL3081406 | 0.80 | DRD3 (0.60) | DRD3DRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079693-B1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | claimed |
| EP-2079693-A1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | F. Hoffmann-Roche AG (CH) | 2009-07-22 | — | — | EP | claimed |
| WO-2008052899-A1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | F. HOFFMANN-LA ROCHE AG (CH) | 2008-05-08 | — | — | WO | claimed |
| EP-2079693-B1 | ETHER DERIVATIVES DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS | HOFFMANN LA ROCHE (CH) | 2013-02-27 | — | — | EP | disclosed |