SCHEMBL4077545

SCHEMBL4077545

[2H][13C]([2H])([2H])c1ccccc1COC(=O)C=C

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
THRB P10828 5/20 0.43
THRA P10827 2/20 0.40
F13A1 P00488 1/20 0.37
TGM2 P21980 1/20 0.37
TGM1 P22735 1/20 0.37
MAOB P27338 2/20 0.37
ALDH1A1 P00352 5/20 0.36
MAPT P10636 2/20 0.36
L3MBTL1 Q9Y468 1/20 0.36
TSHR P16473 6/20 0.36
LMNA P02545 2/20 0.35
KDM4E B2RXH2 1/20 0.35
ADORA2A P29274 1/20 0.35
HPGD P15428 1/20 0.35
HCAR2 Q8TDS4 1/20 0.35
TP53 P04637 2/20 0.34
HIF1A Q16665 2/20 0.34
CYP3A4 P08684 1/20 0.34
HSD17B10 Q99714 1/20 0.34
NPC1 O15118 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1591973 0.89 MAOB (0.46) THRBTHRAF13A1TGM2TGM1
SCHEMBL29577996 0.83 THRB (0.53) THRBTHRAALDH1A1TSHRLMNA
SCHEMBL10451653 0.83 THRB (0.53) THRBTHRAALDH1A1TSHRLMNA
SCHEMBL1371361 0.80 THRB (0.47) THRBTHRAALDH1A1MAPTL3MBTL1
SCHEMBL4596466 0.79 ESR1 (0.43) THRBTHRAF13A1TGM2TGM1
SCHEMBL28270007 0.77 THRB (0.39) THRBTHRAF13A1TGM2TGM1
SCHEMBL960201 0.77 IDO1 (0.48) THRBTHRAALDH1A1TSHRHCAR2
SCHEMBL9555275 0.77 THRB (0.47) THRBTHRAALDH1A1TSHRLMNA
SCHEMBL7181027 0.77 THRB (0.47) THRBTHRAALDH1A1TSHRLMNA
SCHEMBL25491940 0.76 THRB (0.44) THRBTHRAALDH1A1TSHRLMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2081879-A2 SYNTHESIS OF ISOTOPICALLY LABELED ALPHA-KETO ACIDS AND ESTERS Cambridge Isotope Laboratories, Inc. (US) 2009-07-29 EP claimed
WO-2008011033-A2 SYNTHESIS OF ISOTOPICALLY LABELED ALPHA-KETO ACIDS AND ESTERS SPECTRA GASES, INC. (US) 2008-01-24 WO claimed
EP-2081879-A2 SYNTHESIS OF ISOTOPICALLY LABELED ALPHA-KETO ACIDS AND ESTERS Cambridge Isotope Laboratories, Inc. (US) 2009-07-29 EP disclosed
WO-2008011033-A2 SYNTHESIS OF ISOTOPICALLY LABELED ALPHA-KETO ACIDS AND ESTERS SPECTRA GASES, INC. (US) 2008-01-24 WO disclosed