Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.37 |
| ▸ | MAPT | P10636 | 8/20 | 0.37 |
| ▸ | GAA | P10253 | 6/20 | 0.37 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 3/20 | 0.36 |
| ▸ | TTK | P33981 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 3/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 2/20 | 0.34 |
| ▸ | AURKA | O14965 | 2/20 | 0.34 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.34 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.34 |
| ▸ | PAK4 | O96013 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | CSF1R | P07333 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 2/20 | 0.34 |
| ▸ | LTK | P29376 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883718 | 0.84 | AXL (0.38) | JAK2MAPTGAATP53TTK | |
| SCHEMBL13883576 | 0.82 | JAK2 (0.40) | JAK2PTK2MAPTGAATP53 | |
| SCHEMBL13883627 | 0.82 | JAK2 (0.37) | JAK2PTK2TTKJAK1CLK4 | |
| SCHEMBL13883626 | 0.81 | IKBKB (0.41) | JAK2TTKJAK1CLK4AURKA | |
| SCHEMBL3971650 | 0.81 | TNIK (0.39) | JAK2PTK2JAK1CLK4CHEK1 | |
| SCHEMBL3973621 | 0.80 | JAK2 (0.38) | JAK2PTK2TTKLMNAJAK1 | |
| SCHEMBL4407227 | 0.79 | JAK1 (0.38) | JAK2PTK2TTKJAK1CLK4 | |
| SCHEMBL4255795 | 0.79 | JAK1 (0.38) | JAK2PTK2TTKLMNAJAK1 | |
| SCHEMBL4081376 | 0.78 | JAK2 (0.40) | JAK2PTK2TTKLMNAJAK1 | |
| SCHEMBL13883557 | 0.78 | IKBKB (0.40) | JAK2PTK2TTKLMNAJAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |