Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 5/20 | 0.36 |
| ▸ | WDR5 | P61964 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 2/20 | 0.34 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.34 |
| ▸ | AXL | P30530 | 1/20 | 0.34 |
| ▸ | MERTK | Q12866 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | SYK | P43405 | 1/20 | 0.33 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.33 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.33 |
| ▸ | EGFR | P00533 | 1/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 1/20 | 0.32 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883718 | 0.88 | AXL (0.38) | TNIKJAK2JAK1PDPK1AXL | |
| SCHEMBL13883626 | 0.85 | IKBKB (0.41) | TNIKJAK2JAK1PDPK1ROCK2 | |
| SCHEMBL4407227 | 0.83 | JAK1 (0.38) | TNIKJAK2JAK1HDAC1AXL | |
| SCHEMBL13883576 | 0.82 | JAK2 (0.40) | TNIKJAK2JAK1ROCK1CHEK1 | |
| SCHEMBL13883627 | 0.82 | JAK2 (0.37) | TNIKJAK2JAK1HDAC1HDAC6 | |
| SCHEMBL4077575 | 0.81 | JAK2 (0.43) | JAK2JAK1ROCK1FLT3CHEK1 | |
| SCHEMBL4085715 | 0.81 | JAK1 (0.39) | TNIKJAK2JAK1HDAC1HDAC6 | |
| SCHEMBL4255795 | 0.80 | JAK1 (0.38) | TNIKJAK2JAK1HDAC1HDAC6 | |
| SCHEMBL13883557 | 0.79 | IKBKB (0.40) | TNIKJAK2JAK1PTK2 | |
| SCHEMBL3974777 | 0.79 | JAK2 (0.43) | JAK2PDPK1HDAC1HDAC6AXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | disclosed |