Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 2/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.52 |
| ▸ | IGF1R | P08069 | 7/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.48 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.48 |
| ▸ | ULK1 | O75385 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4067519 | 0.86 | IGF1R (0.53) | IGF1RNTRK1PAK4PAK1ULK1 | |
| SCHEMBL14324075 | 0.82 | IGF1R (0.51) | AURKAAURKBIGF1RNTRK1PAK4 | |
| SCHEMBL786513 | 0.79 | ULK1 (0.65) | AURKBNTRK1PAK4PAK1ULK1 | |
| SCHEMBL29618398 | 0.79 | ULK1 (0.65) | AURKBNTRK1PAK4PAK1ULK1 | |
| SCHEMBL4068978 | 0.78 | PAK4 (0.59) | IGF1RPAK4PAK1 | |
| SCHEMBL12430601 | 0.76 | AURKB (0.74) | AURKAAURKBIGF1RULK1 | |
| SCHEMBL13054580 | 0.76 | AURKB (0.49) | AURKAAURKBIGF1RNTRK1PAK4 | |
| SCHEMBL14323363 | 0.75 | IGF1R (0.49) | IGF1RNTRK1PAK4PAK1ULK1 | |
| SCHEMBL4071502 | 0.74 | NTRK1 (0.61) | IGF1RNTRK1PAK4PAK1ULK1 | |
| SCHEMBL4068008 | 0.74 | NTRK1 (0.61) | NTRK1PAK4PAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1686999-B1 | PYRAZOLE DERIVATIVES AS INHIBITORS OF RECEPTOR TYROSINE KINASES | ASTRAZENECA AB (SE) | 2009-07-01 | — | — | EP | disclosed |