SCHEMBL407786

SCHEMBL407786

CCOc1ccc(C(CCCc2ccc(F)c(Oc3ccccc3)c2)C(F)(F)F)cc1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LTA4H P09960 2/20 0.41
SIGMAR1 Q99720 1/20 0.37
L3MBTL1 Q9Y468 2/20 0.37
LMNA P02545 2/20 0.37
MAPT P10636 1/20 0.37
ATM Q13315 1/20 0.37
FDFT1 P37268 2/20 0.36
PPARG P37231 2/20 0.36
PPARD Q03181 1/20 0.36
PPARA Q07869 1/20 0.36
CETP P11597 1/20 0.36
MEN1 O00255 2/20 0.36
KMT2A Q03164 2/20 0.36
CACNA1C Q13936 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
SLC6A2 P23975 1/20 0.34
SLC6A4 P31645 1/20 0.34
SLC6A3 Q01959 1/20 0.34
CNR2 P34972 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9804252 0.90 FDFT1 (0.35) LTA4HSIGMAR1L3MBTL1LMNAMAPT
SCHEMBL7929110 0.87 FDFT1 (0.37) FDFT1
SCHEMBL9493734 0.87 CETP (0.40) LTA4HFDFT1CETPSLC6A2SLC6A4
SCHEMBL10549602 0.86 LTA4H (0.42) LTA4HSIGMAR1L3MBTL1LMNAFDFT1
SCHEMBL10549349 0.85 LTA4H (0.41) LTA4HSIGMAR1L3MBTL1LMNAFDFT1
SCHEMBL7931627 0.85 CETP (0.49) LTA4HFDFT1CETP
SCHEMBL7934903 0.84 TTR (0.41) FDFT1
SCHEMBL10650344 0.84 LTA4H (0.39) LTA4HSIGMAR1L3MBTL1LMNAFDFT1
SCHEMBL10652023 0.84 LTA4H (0.39) LTA4HSIGMAR1L3MBTL1LMNAFDFT1
SCHEMBL409992 0.83 LTA4H (0.41) LTA4HL3MBTL1LMNAMAPTATM

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE37087-E1 1-(4-ETHOXYPHENYL)-4-(4-FLUORO-3-PHENOXYPHENYL)-1 -TRIFLUOROMETHYLBUTANE OR 1-(4-ETHOXY-3-FLUOROPHENYL)-4-(3-PHENOXYPHENYL)-1-TRIFLUOROMETHYLBUTANE, FOR EXAMPLE; COMBATS INSECTS AND MITES SCHERING AKTIENGESELLSCHAFT (DE) 2001-03-06 US claimed
EP-0240121-B1 DIPHENYL ETHER DERIVATIVES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1991-04-17 EP claimed
EP-0415568-A2 Insecticidal compositions IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1991-03-06 EP claimed
US-4791139-A Diphenyl ether derivatives and their use as insecticides IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-12-13 US claimed
EP-0240121-A2 Diphenyl ether derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-10-07 EP claimed
EP-2376219-B1 METHOD FOR CONTROLLING WATER EVAPORATION UNIV MELBOURNE (AU) 2018-03-14 EP disclosed
US-8696987-B2 Method for controlling water evaporation POLYMERS CRC LTD (AU) 2014-04-15 US disclosed
US-20120018387-A1 METHOD FOR CONTROLLING WATER EVAPORATION POLYMERS CRC LTD (AU) 2012-01-26 US disclosed
EP-2376219-A1 METHOD FOR CONTROLLING WATER EVAPORATION Polymers CRC Limited (AU) 2011-10-19 EP disclosed
WO-1994008931-A1 PROCESS AND INTERMEDIATES FOR THE PREPARATION OF SUBSTITUTED 2-PHENYL-5-(3-PHENOXYPHENYL)-1,1,1-TRIFLUOROPENTANES SCHERING AKTIENGESELLSCHAFT (DE) 1994-04-28 WO disclosed
EP-0240121-B1 DIPHENYL ETHER DERIVATIVES IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1991-04-17 EP disclosed
EP-0415568-A2 Insecticidal compositions IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1991-03-06 EP disclosed
EP-0390228-A2 Chemical intermediates IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-10-03 EP disclosed
US-4870218-A Trihalobenzene compounds IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1989-09-26 US disclosed
US-4791139-A Diphenyl ether derivatives and their use as insecticides IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-12-13 US disclosed
US-4788349-A Halogenated diphenyl ether derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-11-29 US disclosed
EP-0252592-A1 Halogenated diphenyl ether derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1988-01-13 EP disclosed
EP-0240121-A2 Diphenyl ether derivatives IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1987-10-07 EP disclosed