Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 5/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.37 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.37 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.35 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.35 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2825730 | 0.92 | MAPK13 (0.38) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL2076784 | 0.91 | MAPK14 (0.42) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL2826952 | 0.85 | MAPK14 (0.44) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL2829217 | 0.84 | EGFR (0.39) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL2079338 | 0.84 | MAPK14 (0.43) | MAPK14MAPK13MAPK12MAPK11LMNA | |
| SCHEMBL2832374 | 0.83 | RORB (0.41) | MAPK14MAPK13MAPK12MAPK11MAPT | |
| SCHEMBL2081424 | 0.80 | RIPK1 (0.36) | MAPK14MAPTGSK3BSYKLMNA | |
| SCHEMBL1643725 | 0.77 | MAPK14 (0.57) | MAPK14MAPK13MAPK12MAPK11CES2 | |
| SCHEMBL4070987 | 0.75 | P2RY1 (0.33) | MAPTGSK3BSYKLMNAABL1 | |
| SCHEMBL2828600 | 0.73 | RORB (0.44) | MAPK14MAPK13MAPK12MAPK11MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049537-A1 | 1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | Laboratorios Almirall, S.A. (ES) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008017461-A1 | 1, 7-NAPHTHYRIDINE DERIVATIVES AS P38 MAP KINASE INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2008-02-14 | — | — | WO | disclosed |