Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.48 |
| ▸ | DHODH | Q02127 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | AGER | Q15109 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2745986 | 0.88 | KMT2A (0.47) | KMT2ADHODHMAPTMEN1ALDH1A1 | |
| SCHEMBL6209129 | 0.85 | NR4A1 (0.50) | KMT2ADHODHGAAMEN1L3MBTL1 | |
| SCHEMBL8833877 | 0.82 | KDM4E (0.59) | KMT2ADHODHMAPTGAAMEN1 | |
| SCHEMBL2783136 | 0.81 | KMT2A (0.51) | KMT2AMAPTMEN1ALDH1A1KDM4E | |
| SCHEMBL8764829 | 0.80 | CTNNB1 (0.44) | KMT2AALDH1A1KDM4EL3MBTL1NPC1 | |
| SCHEMBL3709112 | 0.79 | SMN1; SMN2 (0.67) | KMT2AAKR1C3DHODHMAPTGAA | |
| SCHEMBL8833113 | 0.77 | KDM4E (0.42) | KMT2AMAPTGAAMEN1ALDH1A1 | |
| SCHEMBL187899 | 0.77 | ALDH1A1 (0.55) | KMT2AAKR1C3DHODHMAPTGAA | |
| SCHEMBL29710001 | 0.77 | AKR1C3 (0.53) | KMT2AAKR1C3DHODHMAPTGAA | |
| SCHEMBL6164224 | 0.77 | PARP1 (0.53) | MAPTALDH1A1KDM4ETDP1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1732917-B1 | SELECTED CGRP ANTAGONISTS, METHODS FOR THE PRODUCTION THEREOF AND THEIR USE AS MEDICAMENTS | BOEHRINGER INGELHEIM PHARMA (DE) | 2009-07-29 | — | — | EP | disclosed |