Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 3/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | NAPRT | Q6XQN6 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | AHR | P35869 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | BLM | P54132 | 1/20 | 0.41 |
| ▸ | AGER | Q15109 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12754874 | 0.83 | PARP1 (0.51) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL2718276 | 0.83 | PARP1 (0.56) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9596105 | 0.83 | PARP1 (0.56) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8833877 | 0.82 | KDM4E (0.59) | KDM4EALDH1A1NAPRTMAPTSMN1; SMN2 | |
| SCHEMBL8833113 | 0.81 | KDM4E (0.42) | PARP1KDM4EALDH1A1NAPRTMAPT | |
| SCHEMBL833521 | 0.78 | NPC1 (0.58) | PARP1KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL7473485 | 0.77 | GAA (0.44) | KDM4EALDH1A1MAPTTDP1TSHR | |
| SCHEMBL7473927 | 0.77 | P2RX7 (0.40) | KDM4EALDH1A1HPGDHSD17B10NAPRT | |
| SCHEMBL5984230 | 0.77 | ALDH1A1 (0.42) | PARP1KDM4EALDH1A1NAPRTMAPT | |
| SCHEMBL4078561 | 0.77 | KMT2A (0.49) | KDM4EALDH1A1NAPRTMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1335917-B1 | CONDENSED PYRIDOINDOLE DERIVATIVES | LILLY ICOS LLC (US) | 2005-08-24 | — | — | EP | claimed |
| US-6838456-B2 | Condensed pyridoindole derivatives | LILLY ICOS LLC (US) | 2005-01-04 | — | — | US | claimed |
| US-20030207906-A1 | Chemical compounds | LILLY ICOS LLC | 2003-11-06 | — | — | US | claimed |
| EP-1335917-A2 | CONDENSED PYRIDOINDOLE DERIVATIVES | Lilly Icos LLC (US) | 2003-08-20 | — | — | EP | claimed |
| WO-2002028859-A2 | CONDENSED PYRIDOINDOLE DERIVATIVES | LILLY ICOS LLC (US) | 2002-04-11 | — | — | WO | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207906-A1 | Chemical compounds | ABCG2, SDHA, UGT2B7 | PARP1 3402/4885KDM4E 4342/4885ALDH1A1 435/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.