Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.69 |
| ▸ | GAA | P10253 | 6/20 | 0.69 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.69 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.69 |
| ▸ | APAF1 | O14727 | 2/20 | 0.69 |
| ▸ | CASP1 | P29466 | 2/20 | 0.69 |
| ▸ | CASP7 | P55210 | 2/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | IDH1 | O75874 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5445669 | 0.84 | KDM4E (0.65) | MAPTKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL4072881 | 0.78 | MAPT (0.72) | MAPTKDM4EALDH1A1HSD17B10ALOX15 | |
| SCHEMBL9293461 | 0.75 | KDM4E (0.65) | MAPTKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL5459219 | 0.74 | KDM4E (0.58) | MAPTKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL9293307 | 0.73 | KDM4E (0.65) | MAPTKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL4079416 | 0.71 | KDM4E (0.84) | MAPTKDM4EALDH1A1HSD17B10SMN1; SMN2 | |
| SCHEMBL18168142 | 0.71 | MAPT (0.72) | MAPTKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL18168209 | 0.71 | MAPT (0.72) | MAPTKDM4EALDH1A1GAAHSD17B10 | |
| SCHEMBL13753681 | 0.70 | ALDH1A1 (0.71) | MAPTALDH1A1GAASMN1; SMN2LMNA | |
| SCHEMBL18168163 | 0.70 | MAPT (0.71) | MAPTKDM4EALDH1A1GAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2040711-A2 | 2-OXO-1,2-DIHYDROQUINOLINE DERIVATIVES, COMPOSITIONS, AND USES THEREOF AS ANTIPROLIFERATIVE AGENTS | Amphora Discovery Corporation (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2007136592-A2 | 2-0X0-L,2-DIHYDR0QUIN0LINE DERIVATIVES, COMPOSITIONS, AND USES THEREOF AS ANTIPROLIFERATIVE AGENTS | AMPHORA DISCOVERY CORPORATION (US) | 2007-11-29 | — | — | WO | disclosed |