Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088855 | 0.86 | HSD11B1 (0.34) | HSD11B1 | |
| SCHEMBL4089219 | 0.77 | HSD11B1 (0.30) | HSD11B1 | |
| SCHEMBL75044 | 0.77 | HSD11B1 (0.42) | HSD11B1 | |
| SCHEMBL4078948 | 0.72 | HSD11B1 (0.38) | HSD11B1POLBL3MBTL1 | |
| SCHEMBL4082514 | 0.70 | HSD11B1 (0.37) | HSD11B1 | |
| SCHEMBL75016 | 0.68 | HSD11B1 (0.37) | HSD11B1 | |
| SCHEMBL4083375 | 0.66 | HSD11B1 (0.32) | HSD11B1 | |
| SCHEMBL75421 | 0.61 | HSD11B1 (0.42) | HSD11B1 | |
| SCHEMBL76134 | 0.61 | HSD11B1 (0.45) | HSD11B1 | |
| SCHEMBL75413 | 0.59 | HSD11B1 (0.49) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |