Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 15/20 | 0.40 |
| ▸ | REN | P00797 | 2/20 | 0.34 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.33 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.32 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4078831 | 0.87 | HSD11B1 (0.39) | HSD11B1HSD11B2 | |
| SCHEMBL4088681 | 0.85 | HSD11B1 (0.43) | HSD11B1 | |
| SCHEMBL4086632 | 0.83 | HSD11B1 (0.45) | HSD11B1 | |
| SCHEMBL4088080 | 0.82 | CHRNA1 (0.37) | HSD11B1 | |
| SCHEMBL4078974 | 0.80 | HSD11B1 (0.37) | HSD11B1REN | |
| SCHEMBL4078865 | 0.79 | HSD11B1 (0.45) | HSD11B1HSD11B2 | |
| SCHEMBL4082488 | 0.79 | HSD11B1 (0.39) | HSD11B1RENHSD11B2 | |
| SCHEMBL4082564 | 0.78 | HSD11B1 (0.44) | HSD11B1 | |
| SCHEMBL75282 | 0.77 | HSD11B1 (0.43) | HSD11B1 | |
| SCHEMBL4083825 | 0.76 | HSD11B1 (0.38) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |