Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 16/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.33 |
| ▸ | CHRNG | P07510 | 1/20 | 0.33 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.33 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.33 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
| ▸ | CHRND | Q07001 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4081766 | 1.00 | HSD11B1 (0.38) | HSD11B1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL4078926 | 1.00 | HSD11B1 (0.38) | HSD11B1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL4088681 | 0.89 | HSD11B1 (0.43) | HSD11B1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL4082564 | 0.88 | HSD11B1 (0.44) | HSD11B1 | |
| SCHEMBL4078974 | 0.87 | HSD11B1 (0.37) | HSD11B1 | |
| SCHEMBL4082590 | 0.87 | HSD11B1 (0.46) | HSD11B1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL4083815 | 0.87 | HSD11B1 (0.45) | HSD11B1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL4088080 | 0.86 | CHRNA1 (0.37) | HSD11B1CHRNA1CHRNGCHRNB1CHRNB2 | |
| SCHEMBL4082249 | 0.83 | CTSD (0.40) | HSD11B1SLC6A4SLC6A3 | |
| SCHEMBL4088554 | 0.83 | CCR2 (0.39) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |