Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 3/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 3/20 | 0.33 |
| ▸ | CTSD | P07339 | 1/20 | 0.33 |
| ▸ | BACE1 | P56817 | 1/20 | 0.33 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CCKBR | P32239 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13778596 | 0.71 | TSHR (0.53) | CTSDBACE1BACE2ALDH1A1SMN1; SMN2 | |
| SCHEMBL4233856 | 0.65 | TSHR (0.42) | BACE1BACE2ALDH1A1SMN1; SMN2 | |
| SCHEMBL13435193 | 0.64 | HSD11B1 (0.44) | HSD11B1PRMT5WDR77CTSDBACE1 | |
| SCHEMBL4083793 | 0.64 | FLT3 (0.36) | EPHX2ALOX12HSD11B1CHRM3ALDH1A1 | |
| SCHEMBL4232196 | 0.63 | CYP2C9 (0.55) | ALDH1A1 | |
| SCHEMBL5324640 | 0.63 | EPHX2 (0.51) | EPHX2ALOX12HSD11B1USP2ALDH1A1 | |
| SCHEMBL13558674 | 0.63 | EPHX2 (0.51) | EPHX2ALOX12HSD11B1USP2ALDH1A1 | |
| SCHEMBL1898293 | 0.62 | EPHX2 (0.37) | EPHX2HSD11B1PRMT5WDR77CTSD | |
| SCHEMBL74972 | 0.62 | EPHX2 (0.40) | EPHX2HSD11B1USP2ALDH1A1CCKBR | |
| SCHEMBL75016 | 0.62 | HSD11B1 (0.37) | EPHX2HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |