Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.31 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.31 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.31 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | GSK3B | P49841 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1894670 | 0.65 | FLT3 (0.36) | FLT3EPHX2HSD11B1ALDH1A1PDCD1 | |
| SCHEMBL4078952 | 0.64 | EPHX2 (0.36) | EPHX2CHRM3HSD11B1ALDH1A1ALOX12 | |
| SCHEMBL75577 | 0.61 | FLT3 (0.39) | FLT3EPHX2HSD11B1ALDH1A1GRM1 | |
| SCHEMBL2168618 | 0.61 | GRM1 (0.41) | FLT3HSD11B1ALDH1A1PDCD1CD274 | |
| SCHEMBL5324640 | 0.60 | EPHX2 (0.51) | FLT3EPHX2CHRM2HSD11B1ALDH1A1 | |
| SCHEMBL13558674 | 0.60 | EPHX2 (0.51) | FLT3EPHX2CHRM2HSD11B1ALDH1A1 | |
| SCHEMBL2170191 | 0.59 | HSD11B1 (0.41) | FLT3CHRM2CHRM4HSD11B1ALDH1A1 | |
| SCHEMBL9726361 | 0.58 | PDCD1 (0.50) | EPHX2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL15922579 | 0.57 | CHRM2 (0.37) | EPHX2CHRM2CHRM4CHRM5CHRM1 | |
| SCHEMBL15922580 | 0.57 | CHRM2 (0.37) | EPHX2CHRM2CHRM4CHRM5CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |