Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.36 |
| ▸ | HSD11B2 | P80365 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL75243 | 0.85 | HSD11B1 (0.47) | HSD11B1 | |
| SCHEMBL76369 | 0.82 | CHRM3 (0.33) | HSD11B1CHRM3CHRM2 | |
| SCHEMBL4084349 | 0.82 | CHRM3 (0.33) | HSD11B1CHRM3CHRM2 | |
| SCHEMBL4262880 | 0.82 | HSD11B1 (0.42) | HSD11B1HSD11B2ALDH1A1LMNACNR2 | |
| SCHEMBL75319 | 0.81 | CNR2 (0.41) | ALDH1A1LMNACNR2KDM4ESMN1; SMN2 | |
| SCHEMBL4255753 | 0.79 | CNR2 (0.34) | HSD11B1ALDH1A1LMNACNR2SMN1; SMN2 | |
| SCHEMBL76313 | 0.79 | CNR2 (0.41) | ALDH1A1LMNACNR2KDM4ESMN1; SMN2 | |
| SCHEMBL4253053 | 0.78 | CNR2 (0.40) | HSD11B1ALDH1A1LMNACNR2KDM4E | |
| SCHEMBL75817 | 0.78 | CNR2 (0.40) | HSD11B1ALDH1A1LMNACNR2KDM4E | |
| SCHEMBL4259160 | 0.78 | CNR2 (0.40) | HSD11B1ALDH1A1CNR2KDM4ENPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | claimed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | claimed |