Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 10/20 | 0.42 |
| ▸ | HSD11B2 | P80365 | 4/20 | 0.40 |
| ▸ | CNR2 | P34972 | 3/20 | 0.38 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | IDH1 | O75874 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL75243 | 0.85 | HSD11B1 (0.47) | HSD11B1 | |
| SCHEMBL4084349 | 0.82 | CHRM3 (0.33) | HSD11B1 | |
| SCHEMBL76369 | 0.82 | CHRM3 (0.33) | HSD11B1 | |
| SCHEMBL4261014 | 0.82 | HSD11B1 (0.36) | HSD11B1HSD11B2ALDH1A1 | |
| SCHEMBL4079042 | 0.82 | ESR1 (0.39) | HSD11B1HSD11B2CNR2ALDH1A1LMNA | |
| SCHEMBL4259160 | 0.81 | CNR2 (0.40) | HSD11B1CNR2ALDH1A1KDM4ETSHR | |
| SCHEMBL73719 | 0.81 | CNR2 (0.40) | HSD11B1CNR2ALDH1A1KDM4ETSHR | |
| SCHEMBL4253053 | 0.81 | CNR2 (0.40) | HSD11B1CNR2ALDH1A1LMNAKDM4E | |
| SCHEMBL75817 | 0.81 | CNR2 (0.40) | HSD11B1CNR2ALDH1A1LMNAKDM4E | |
| SCHEMBL4255753 | 0.79 | CNR2 (0.34) | HSD11B1CNR2ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2104665-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. Hoffmann-Roche AG (CH) | 2009-09-30 | — | — | EP | disclosed |
| WO-2008046758-A2 | IMIDAZOLONE AND IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS FOR DIABETES | F. HOFFMANN-LA ROCHE AG (CH) | 2008-04-24 | — | — | WO | disclosed |