Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.40 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 2/20 | 0.39 |
| ▸ | BDKRB1 | P46663 | 6/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | AR | P10275 | 2/20 | 0.36 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.36 |
| ▸ | F3 | P13726 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MPL | P40238 | 1/20 | 0.34 |
| ▸ | PDCD1LG2 | Q9BQ51 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4083769 | 0.90 | OPRM1 (0.42) | OPRM1OPRD1OPRK1HDAC1MAPK14 | |
| SCHEMBL4075483 | 0.88 | OPRK1 (0.39) | OPRM1OPRD1OPRK1BDKRB1HDAC1 | |
| SCHEMBL13633134 | 0.88 | OPRK1 (0.41) | OPRM1OPRD1OPRK1AKR1C3AKR1C2 | |
| Hydrochloric Acid SCHEMBL4072865 | 0.87 | OPRK1 (0.40) | OPRM1OPRD1OPRK1AKR1C3AKR1C2 | |
| SCHEMBL4078534 | 0.87 | OPRM1 (0.41) | OPRM1OPRD1OPRK1AKR1C3AKR1C2 | |
| SCHEMBL4081673 | 0.86 | OPRM1 (0.41) | OPRM1OPRD1OPRK1HDAC1ROCK2 | |
| Hydrochloric Acid SCHEMBL4074231 | 0.86 | OPRM1 (0.41) | OPRM1OPRD1OPRK1AKR1C3AKR1C2 | |
| Hydrochloric Acid SCHEMBL4075476 | 0.85 | OPRM1 (0.40) | OPRM1OPRD1OPRK1AKR1C3AKR1C2 | |
| Hydrochloric Acid SCHEMBL4480314 | 0.83 | SCN9A (0.40) | OPRM1OPRD1OPRK1AKR1C3AKR1C2 | |
| SCHEMBL4073644 | 0.83 | OPRM1 (0.53) | OPRM1OPRD1OPRK1HDAC1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |