Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.72 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.72 |
| ▸ | TSHR | P16473 | 3/20 | 0.72 |
| ▸ | NPC1 | O15118 | 2/20 | 0.72 |
| ▸ | RAB9A | P51151 | 2/20 | 0.72 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.64 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.64 |
| ▸ | AR | P10275 | 1/20 | 0.62 |
| ▸ | LMNA | P02545 | 5/20 | 0.59 |
| ▸ | MEN1 | O00255 | 4/20 | 0.59 |
| ▸ | HTT | P42858 | 2/20 | 0.59 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4075010 | 0.89 | AR (0.76) | MAPTALDH1A1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL9052676 | 0.87 | MAPT (0.69) | MAPTALDH1A1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL8912424 | 0.87 | MAPT (0.72) | MAPTALDH1A1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL8901909 | 0.86 | MAPT (0.67) | MAPTALDH1A1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL8902390 | 0.85 | MAPT (0.66) | MAPTALDH1A1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL9987606 | 0.84 | MAPT (0.67) | MAPTALDH1A1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL5009458 | 0.83 | ALDH1A1 (0.61) | MAPTALDH1A1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL22053945 | 0.82 | MAPT (0.72) | MAPTALDH1A1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL8706041 | 0.81 | MAPT (0.71) | MAPTALDH1A1KMT2ASMN1; SMN2TSHR | |
| SCHEMBL9051544 | 0.81 | MAPT (0.71) | MAPTALDH1A1KMT2ASMN1; SMN2TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1745010-B1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2009-08-05 | — | — | EP | claimed |
| US-20070112007-A1 | Cyclohexyl-1, 4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-05-17 | — | — | US | claimed |
| EP-1745010-B1 | SUBSTITUTED CYCLOHEXYL-1,4-DIAMINE DERIVATIVES | GRUENENTHAL GMBH (DE) | 2009-08-05 | — | — | EP | disclosed |
| US-20070112007-A1 | Cyclohexyl-1, 4-diamine compounds | GRUENENTHAL GMBH (DE) | 2007-05-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070112007-A1 | Cyclohexyl-1, 4-diamine compounds | PKD1, DDC, DPYD | MAPT 1103/4885ALDH1A1 158/4885KMT2A 3604/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.