Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLPP | Q16740 | 8/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 5/20 | 0.40 |
| ▸ | CCR2 | P41597 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | RGS12 | O14924 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.35 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.35 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.35 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.35 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.35 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4088753 | 0.75 | POLB (0.46) | CLPPUSP2KMT2AKDM4EMEN1 | |
| SCHEMBL4181990 | 0.73 | CLPP (0.52) | CLPPGRIN1GRIN2BCCR2MAPT | |
| SCHEMBL26703806 | 0.65 | CLPP (0.69) | CLPPCCR2POLB | |
| SCHEMBL11795456 | 0.65 | ALDH1A1 (0.45) | KMT2AALDH1A1ROCK2PSEN1PSEN2 | |
| SCHEMBL26707516 | 0.65 | CLPP (0.67) | CLPPCCR2MAPTP2RX3 | |
| SCHEMBL26704966 | 0.63 | CLPP (0.61) | CLPPCCR2KMT2AKDM4EMEN1 | |
| SCHEMBL364974 | 0.60 | GRIN1 (0.49) | CLPPGRIN1GRIN2BCCR2KMT2A | |
| SCHEMBL22028740 | 0.60 | CLPP (1.00) | CLPP | |
| SCHEMBL31547384 | 0.60 | CLPP (1.00) | CLPP | |
| SCHEMBL4184996 | 0.60 | KDM4E (0.61) | GRIN1GRIN2BUSP2KMT2AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009041905-A1 | PTERIDINE COMPOUNDS HAVING ACTIVITY ON THE GABA- RECEPTORS | ASTRAZENECA AB (SE) | 2009-04-02 | — | — | WO | claimed |