Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TUBB4A | P04350 | 7/20 | 0.51 |
| ▸ | TUBB | P07437 | 7/20 | 0.51 |
| ▸ | TUBA3C | P0DPH7 | 7/20 | 0.51 |
| ▸ | TUBA1B | P68363 | 7/20 | 0.51 |
| ▸ | TUBA4A | P68366 | 7/20 | 0.51 |
| ▸ | TUBB4B | P68371 | 7/20 | 0.51 |
| ▸ | TUBB3 | Q13509 | 7/20 | 0.51 |
| ▸ | TUBB2A | Q13885 | 7/20 | 0.51 |
| ▸ | TUBB8 | Q3ZCM7 | 7/20 | 0.51 |
| ▸ | TUBA3E | Q6PEY2 | 7/20 | 0.51 |
| ▸ | TUBA1A | Q71U36 | 7/20 | 0.51 |
| ▸ | TUBA1C | Q9BQE3 | 7/20 | 0.51 |
| ▸ | TUBB6 | Q9BUF5 | 7/20 | 0.51 |
| ▸ | TUBB2B | Q9BVA1 | 7/20 | 0.51 |
| ▸ | TUBB1 | Q9H4B7 | 7/20 | 0.51 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL405705 | 0.91 | TUBB4A (0.58) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL406415 | 0.84 | TUBB4A (0.52) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL408988 | 0.78 | TUBB4A (0.56) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL2336592 | 0.75 | COMT (0.53) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL27592386 | 0.75 | COMT (0.61) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL15166929 | 0.75 | TUBB4A (0.60) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL27911610 | 0.73 | COMT (0.52) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL27915267 | 0.71 | LMNA (0.48) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL23547205 | 0.70 | TUBB4A (0.68) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A | |
| SCHEMBL27875245 | 0.69 | TUBB4A (0.64) | TUBB4ATUBBTUBA3CTUBA1BTUBA4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2408743-A1 | CARBAMATE DERIVATIVES IN PARTICULAR FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | SIGMA-TAU Industrie Farmaceutiche Riunite S.p.A. (IT) | 2012-01-25 | — | — | EP | disclosed |
| WO-2010105930-A1 | CARBAMATE DERIVATIVES IN PARTICULAR FOR THE TREATMENT OF NEUROLOGICAL DISORDERS | SIGMA-TAU INDUSTRIE FARMACEUTICHE RIUNITE S.P.A. (IT) | 2010-09-23 | — | — | WO | disclosed |