Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 7/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.54 |
| ▸ | OPRK1 | P41145 | 7/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | SMO | Q99835 | 6/20 | 0.48 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MTTP | P55157 | 2/20 | 0.40 |
| ▸ | HTR5A | P47898 | 1/20 | 0.39 |
| ▸ | APOB | P04114 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4084233 | 0.86 | OPRM1 (0.57) | OPRM1OPRD1OPRK1HDAC1SMO | |
| SCHEMBL12651507 | 0.85 | HDAC1 (0.52) | OPRM1OPRD1OPRK1HDAC1SMO | |
| Hydrochloric Acid SCHEMBL3345693 | 0.84 | HDAC1 (0.51) | OPRM1OPRD1OPRK1HDAC1SMO | |
| SCHEMBL4083151 | 0.84 | OPRM1 (0.50) | OPRM1OPRD1OPRK1HDAC1SMO | |
| SCHEMBL4478715 | 0.81 | OPRM1 (0.64) | OPRM1OPRD1OPRK1HDAC1SMO | |
| SCHEMBL1785708 | 0.81 | HDAC1 (0.60) | OPRM1OPRD1OPRK1HDAC1FYN | |
| SCHEMBL4081847 | 0.81 | OPRM1 (0.54) | OPRM1OPRD1OPRK1HDAC1SMO | |
| SCHEMBL12650975 | 0.81 | HDAC1 (0.52) | OPRM1OPRD1OPRK1HDAC1FYN | |
| SCHEMBL4074727 | 0.80 | OPRM1 (0.55) | OPRM1OPRD1OPRK1HDAC1FYN | |
| SCHEMBL12607941 | 0.78 | OPRM1 (0.55) | OPRM1OPRD1OPRK1HDAC1SMO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |