Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 5/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | SMO | Q99835 | 5/20 | 0.41 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | MTTP | P55157 | 1/20 | 0.39 |
| ▸ | VNN1 | O95497 | 2/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4072878 | 0.88 | OPRM1 (0.48) | OPRM1OPRD1OPRK1HDAC1FYN | |
| SCHEMBL4080179 | 0.84 | OPRM1 (0.54) | OPRM1OPRD1OPRK1HDAC1SMO | |
| SCHEMBL4084233 | 0.82 | OPRM1 (0.57) | OPRM1OPRD1OPRK1HDAC1SMO | |
| SCHEMBL12651507 | 0.78 | HDAC1 (0.52) | OPRM1OPRD1OPRK1HDAC1SMO | |
| SCHEMBL4071959 | 0.78 | OPRM1 (0.53) | OPRM1OPRD1OPRK1HDAC1SMO | |
| Hydrochloric Acid SCHEMBL3345693 | 0.78 | HDAC1 (0.51) | OPRM1OPRD1OPRK1HDAC1SMO | |
| SCHEMBL4478715 | 0.77 | OPRM1 (0.64) | OPRM1OPRD1OPRK1HDAC1SMO | |
| SCHEMBL1785708 | 0.77 | HDAC1 (0.60) | OPRM1OPRD1OPRK1HDAC1SLC2A1 | |
| SCHEMBL4075715 | 0.76 | HDAC1 (0.48) | OPRM1OPRD1OPRK1HDAC1SMO | |
| SCHEMBL38652244 | 0.75 | AKT1 (0.51) | AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |
| EP-2084127-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | Pfizer Products Inc. (US) | 2009-08-05 | — | — | EP | claimed |
| WO-2008059335-A1 | DIARYL, DIPYRIDINYL AND ARYL-PYRIDINYL DERIVATIVES AND USES THEREOF | PFIZER PRODUCTS INC. (US) | 2008-05-22 | — | — | WO | claimed |