Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 15/20 | 0.68 |
| ▸ | GABRB3 | P28472 | 15/20 | 0.68 |
| ▸ | GABRA3 | P34903 | 15/20 | 0.68 |
| ▸ | GABRA2 | P47869 | 11/20 | 0.68 |
| ▸ | GABRA5 | P31644 | 11/20 | 0.68 |
| ▸ | GABRA1 | P14867 | 9/20 | 0.68 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.66 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.66 |
| ▸ | GABRB2 | P47870 | 4/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL637586 | 0.99 | GABRG2 (0.67) | GABRG2GABRB3GABRA3GABRA2GABRA5 | |
| Hydrochloric Acid SCHEMBL637973 | 0.98 | GABRG2 (0.66) | GABRG2GABRB3GABRA3GABRA2GABRA5 | |
| Hydrochloric Acid SCHEMBL640016 | 0.97 | GABRG2 (0.68) | GABRG2GABRB3GABRA3GABRA2GABRA5 | |
| SCHEMBL638697 | 0.96 | GABRG2 (0.71) | GABRG2GABRB3GABRA3GABRA2GABRA5 | |
| SCHEMBL637411 | 0.94 | GABRG2 (0.69) | GABRG2GABRB3GABRA3GABRA2GABRA5 | |
| SCHEMBL638140 | 0.91 | GABRG2 (0.72) | GABRG2GABRB3GABRA3GABRA2GABRA5 | |
| SCHEMBL637279 | 0.88 | GABRG2 (0.71) | GABRG2GABRB3GABRA3GABRA2GABRA5 | |
| SCHEMBL638683 | 0.88 | GABRA3 (0.68) | GABRG2GABRB3GABRA3GABRA2GABRA5 | |
| SCHEMBL637898 | 0.88 | GABRG2 (0.70) | GABRG2GABRB3GABRA3GABRA2GABRA5 | |
| Hydrochloric Acid SCHEMBL4159931 | 0.88 | GABRG2 (0.70) | GABRG2GABRB3GABRA3GABRA2GABRA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046004-A1 | CARBOXAMIDE GABAA ALPHA2 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-04-09 | — | — | WO | disclosed |