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GABRA3

Gamma-aminobutyric acid receptor subunit alpha-3 · P34903 · GABRA3 on Sugi Atlas →

184,733 patent compounds predicted against GABRA3, 92,418 high-confidence (nearest known ligand ≥ 0.5)

Top predicted compounds (top 20 by supporting neighbours, then confidence)

CompoundConfidenceSupporting neighbours
SCHEMBL15406 SCHEMBL15406 0.61 20/20
Fipronil Fipronil (SCHEMBL15088) 0.59 20/20
SCHEMBL41972 SCHEMBL41972 0.59 20/20
Fipronil Fipronil (SCHEMBL44222) 0.59 20/20
Ethiprole Ethiprole (SCHEMBL27048) 0.56 20/20
SCHEMBL25897 SCHEMBL25897 0.51 20/20
SCHEMBL103712 SCHEMBL103712 0.67 19/20
SCHEMBL33214 SCHEMBL33214 0.52 19/20
SCHEMBL26584 SCHEMBL26584 0.51 19/20
SCHEMBL104346 SCHEMBL104346 0.68 18/20
SCHEMBL104133 SCHEMBL104133 0.66 18/20
Flumazenil Flumazenil (SCHEMBL79030) 1.00 14/20
Iomazenil Iomazenil (SCHEMBL41658) 0.71 12/20
SCHEMBL9107 SCHEMBL9107 0.56 12/20
SCHEMBL8532 SCHEMBL8532 1.00 11/20
SCHEMBL9035 SCHEMBL9035 0.56 10/20
SCHEMBL8632 SCHEMBL8632 0.54 10/20
Flunitrazepam Flunitrazepam (SCHEMBL44169) 1.00 9/20
SCHEMBL8670 SCHEMBL8670 0.57 9/20
SCHEMBL8856 SCHEMBL8856 0.53 9/20

Clinical trials — most relevant to GABRA3 by text similarity (a relevance ranking, not an exhaustive list)

TrialPhaseStatus
Computational Assessment of GABA Receptor Modulation in PTSD PHASE4RECRUITING
Safety of Ramelteon in Elderly Subjects PHASE4COMPLETED
Attenuate the Stress Response in Laparoscopic Cholecystectomy PHASE4NOT_YET_RECRUITING
The Effects of Levetiracetam on Alcohol Dependent Subjects PHASE4COMPLETED
Effects of Ciprofol on Myocardial Injury After Non-cardiac Surgery in Video-Assisted Thoracoscopic Surgery PHASE4RECRUITING
The Effect of Oral Baclofen and Botulinum Toxin Treatments in Hemiplegic Spasticity on the Nociceptive Flexor Reflex PHASE4COMPLETED
Safety and Efficacy Study of Ramelteon in Subjects With Chronic Insomnia PHASE3COMPLETED
Safety and Efficacy of Ramelteon and Doxepin in Subjects With Chronic Insomnia PHASE2COMPLETED
Efficacy and Safety of Ramelteon Combined With Gabapentin in Treating Patients With Insomnia PHASE2COMPLETED
Diazepam Trial in GAD65 Associated Epilepsy PHASE1/PHASE2WITHDRAWN
Efficacy of Bumetanide to Improve Cognitive Functions in Down Syndrome PHASE2RECRUITING
PET Imaging of Brain Peripheral Benzodiazepine Receptors PHASE1COMPLETED
PET Whole Body Imaging Using a Peripheral Benzodiazepine Receptor Ligand [C-11]PBR28 PHASE1COMPLETED
Physiologic Effects of Topiramate on Cognition PHASE1COMPLETED
Imaging the Effects of Zolpidem and Alprazolam in Healthy Volunteers at 3T EARLY_PHASE1UNKNOWN
MEG Study of Acute STX209 Effects in ASD EARLY_PHASE1COMPLETED
Cenobamate Efficacy in Individuals With Autoimmune Epilepsy nanENROLLING_BY_INVITATION
GABA Biomarkers in Dravet Syndrome nanRECRUITING
Association of Brain Derived Neurotrophic Factor (BDNF) rs6265 Gene Polymorphism With Susceptibility to Epilepsy nanUNKNOWN
Assessment of Peripheral GABA Receptors for Local Pain Relief nanUNKNOWN
Integrins and Protocadherins in Glutamatergic Circuits: Identification of Common Signaling Pathways and Molecular Targets in Anxiety and Major Depressive Disorders (GAPsy) nanUNKNOWN
Gene-STEPS: Shortening Time of Evaluation in Paediatric Epilepsy Services nanUNKNOWN
Remifentanil and Remimazolam to Limit Patient Movement nanRECRUITING
Brain Changes in Patients With Focal Hand Dystonia nanCOMPLETED
The Efficacy of Tianeptine Versus Pregabalin on Acute and Chronic Post Mastectomy Pain After Breast Cancer Surgery. nanCOMPLETED
Functional Study of Inhibitory Neurotransmission in the Human Epileptic Brain. nanRECRUITING
Investigating the Role of Diazepam on Brain Function and Chemistry in Psychosis Risk nanCOMPLETED
Effects of Flumazenil on Brain Excitability nanCOMPLETED
GABRA2 and the Pharmacokinetics of Risk for Alcoholism (GPRA) nanCOMPLETED
Protocol Assessment of Motor Cortex rTMS for Treating Neuropathic Pain nanRECRUITING

Related proteins — ESM-2 sequence neighbours (a GABRA3 binder may also engage these)

ProteinNameSimilarity
P26049 — 1.000 P26049 →
P10064 — 1.000 P10064 →
P20236 — 1.000 P20236 →
Q90845 — 0.987 Q90845 →
GABRA6 Gamma-aminobutyric acid receptor subunit alpha-6 0.984 landscape →
P30191 — 0.979 P30191 →
P16305 — 0.978 P16305 →
P19150 — 0.976 P19150 →
Q5R6B2 — 0.974 Q5R6B2 →
P62812 — 0.972 P62812 →
P62813 — 0.972 P62813 →
Q4R534 — 0.971 Q4R534 →
P08219 — 0.971 P08219 →
GABRA1 Gamma-aminobutyric acid receptor subunit alpha-1 0.971 landscape →
Q08E50 — 0.971 Q08E50 →
P19969 — 0.970 P19969 →
P24045 — 0.970 P24045 →
GABRA5 Gamma-aminobutyric acid receptor subunit alpha-5 0.969 landscape →
Q8BHJ7 — 0.966 Q8BHJ7 →
P20237 — 0.961 P20237 →
P22300 — 0.961 P22300 →
P28471 — 0.960 P28471 →
P23574 — 0.960 P23574 →
Q9D6F4 — 0.959 Q9D6F4 →
GABRA4 Gamma-aminobutyric acid receptor subunit alpha-4 0.959 landscape →
GABRG2 Gamma-aminobutyric acid receptor subunit gamm 0.958 landscape →
Q9R0Y8 — 0.957 Q9R0Y8 →
P18508 — 0.957 P18508 →
P22723 — 0.956 P22723 →
GABRG1 Gamma-aminobutyric acid receptor subunit gamm 0.955 landscape →