Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 12/20 | 0.46 |
| ▸ | CDK1 | P06493 | 2/20 | 0.40 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | JAK3 | P52333 | 2/20 | 0.39 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | BRD2 | P25440 | 1/20 | 0.35 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.35 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4081321 | 0.78 | AXL (0.48) | AXLCDK1KDRJAK2JAK3 | |
| SCHEMBL13881489 | 0.76 | BRD4 (0.54) | AXLCDK1KDRJAK2JAK3 | |
| SCHEMBL13881583 | 0.75 | AXL (0.54) | AXLCDK1KDRJAK2JAK3 | |
| SCHEMBL4085714 | 0.74 | JAK1 (0.38) | CDK1KDRJAK2JAK3PTK2 | |
| SCHEMBL3964134 | 0.72 | AXL (0.46) | AXLCDK1KDRJAK2JAK3 | |
| SCHEMBL3965863 | 0.71 | JAK3 (0.61) | AXLKDRJAK2JAK3PTK2 | |
| SCHEMBL2723335 | 0.70 | JAK3 (0.61) | AXLCDK1KDRJAK2JAK3 | |
| Hydrochloric Acid SCHEMBL2730396 | 0.69 | JAK3 (0.59) | AXLCDK1KDRJAK2JAK3 | |
| SCHEMBL3971111 | 0.68 | AXL (0.55) | AXLKDRJAK2JAK3PTK2 | |
| SCHEMBL3971237 | 0.67 | AXL (0.53) | AXLCDK1KDRJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | claimed |
| WO-2009046416-A1 | ANILINOPYRIMIDINES AS JAK KINASE INHIBITORS | TARGEGEN INC. (US) | 2009-04-09 | — | — | WO | disclosed |