Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 6/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | CDK1 | P06493 | 4/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 4/20 | 0.33 |
| ▸ | CDK2 | P24941 | 2/20 | 0.33 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.33 |
| ▸ | CDK7 | P50613 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
| ▸ | CCNH | P51946 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.32 |
| ▸ | KDR | P35968 | 5/20 | 0.32 |
| ▸ | CA1 | P00915 | 2/20 | 0.32 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | CA9 | Q16790 | 2/20 | 0.32 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.32 |
| ▸ | CA12 | O43570 | 1/20 | 0.32 |
| ▸ | AURKA | O14965 | 3/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13883626 | 0.83 | IKBKB (0.41) | JAK1JAK2CDK1CDK5CDK2 | |
| SCHEMBL4085715 | 0.80 | JAK1 (0.39) | JAK1JAK2HDAC1HDAC6CDK5 | |
| SCHEMBL13883576 | 0.78 | JAK2 (0.40) | JAK1JAK2CDK5KDRTNIK | |
| SCHEMBL4407227 | 0.78 | JAK1 (0.38) | JAK1JAK2HDAC1CDK7CDK9 | |
| SCHEMBL13883718 | 0.77 | AXL (0.38) | JAK1JAK2TNIKPDPK1 | |
| SCHEMBL4255795 | 0.76 | JAK1 (0.38) | JAK1JAK2HDAC1HDAC6CDK5 | |
| SCHEMBL4409833 | 0.74 | TNIK (0.37) | JAK1JAK2HDAC1HDAC6CDK5 | |
| SCHEMBL3971650 | 0.74 | TNIK (0.39) | JAK1JAK2HDAC1HDAC6AGTR2 | |
| SCHEMBL3973621 | 0.74 | JAK2 (0.38) | JAK1JAK2CDK5KDRTNIK | |
| SCHEMBL4081315 | 0.74 | AXL (0.46) | JAK2CDK1KDRAURKAJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009049028-A1 | PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS | TARGEGEN INC. (US) | 2009-04-16 | — | — | WO | claimed |